Ciliary Vesicle Formation: A Prelude to Ciliogenesis
نویسندگان
چکیده
منابع مشابه
WDR8 is a centriolar satellite and centriole-associate protein that promotes ciliary vesicle docking during ciliogenesis
Ciliogenesis initiates at the mother centriole through a series of events that include membrane-docking, displacement of cilia-inhibitory proteins and axoneme elongation. Centriolar proteins, in particular at distal and subdistal appendages, carry out these functions. Recently, cytoplasmic complexes named centriolar satellites were also shown to promote ciliogenesis. Little is known about the f...
متن کاملWDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.
Ciliogenesis initiates at the mother centriole through a series of events that include membrane docking, displacement of cilia-inhibitory proteins and axoneme elongation. Centriolar proteins, in particular at distal and subdistal appendages, carry out these functions. Recently, cytoplasmic complexes named centriolar satellites have also been shown to promote ciliogenesis. Little is known about ...
متن کاملScoring a backstage pass: Mechanisms of ciliogenesis and ciliary access
Cilia are conserved, microtubule-based cell surface projections that emanate from basal bodies, membrane-docked centrioles. The beating of motile cilia and flagella enables cells to swim and epithelia to displace fluids. In contrast, most primary cilia do not beat but instead detect environmental or intercellular stimuli. Inborn defects in both kinds of cilia cause human ciliopathies, diseases ...
متن کاملPrelude to a Kiss
We consider expanding maps of the circle with an almost neutral fixed point c. In this setting the ergodic averages of a smooth observable A satisfy the Central Limit Theorem. If A(c) = 0 we show that the expectation and the variance behave as the square root of the multiplier of c times rapidly oscillating functions of parameters.
متن کاملSmall molecule inhibitors of Smoothened ciliary localization and ciliogenesis.
Vertebrate Hedgehog (Hh) signals involved in development and some forms of cancer, such as basal cell carcinoma, are transduced by the primary cilium, a microtubular projection found on many cells. A critical step in vertebrate Hh signal transduction is the regulated movement of Smoothened (Smo), a seven-transmembrane protein, to the primary cilium. To identify small molecules that interfere wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Cell
سال: 2015
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2015.03.012